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Research Links

A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice

Chronic treatment with carboxyfullerene not only reduced age-associated oxidative stress and mitochondrial radical production, but significantly extended lifespan and rescued age-related cognitive impairment in mammals.

The prolongation of the lifespan of rats by repeated oral administration of [60] fullerene

This study was to determine C60 toxicity. Not only was C60 found to be non-toxic to rats (even at high doses intended to discern toxic levels), but they found their specimens lived notably longer than expected (and might have lived longer still if allowed to die of natural causes). This study strongly suggests that the effect on lifespan is mainly due to the antioxidant activity of C60. These results have opened the way for other possible biomedical applications of C60 including cancer therapy, neurodegenerative disorders, and ageing.

The Polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune & mitochondrial dysfunction

Pretreating rats for 2 weeks with C60(OH)24 prior to irradiation treatment, effectively reduced the expected mortality of irradiation without any apparent toxicity; and showed an ability to protect the immune system, mitochondrial function, and antioxidant defense in the liver and spleen.

Pristine C60 Fullerenes inhibit the rate of tumor growth and metastasis

Pristine C60 fullerenes inhibited the growth of tumors & extended life expectancy. The results can be explained by way of the high antioxidant activity of C60 fullerenes, not only neutralizing oxidants, but possibly also blocking specific cell receptors. *PDF requires purchase; abstract is free.

C60 Fullerenes as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

C60 can bond with up to 6 electrons, which makes it a potential powerful antioxidant against muscle fatigue. After C60 treatment, performance levels were prolonged, and the rate of decline was notably reduced. Furthermore, the recovery time was also reduced, and muscle endurance increased. Potentially making C60 a boon to athletes!

Effects of Carbon Nanoparticles on the Agregation of Alzheimers Beta-Amyloid Peptide

Alzheimer's Disease is associated with beta-amyloid plaques in the brain. Fullerene derivatives strongly inhibit beta-amyloid fibrillation, by encouraging the broken enzymes to coil up into a non-reactive structure, instead of tangling-up and contributing to plaque formation.

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